Through our clinical trial capabilities, we provide our patients access to the most advanced heart and vascular treatments. We are currently participating in more than 115 heart and vascular clinical trials
Here are just a few:

OhioHealth is participating in COAPT, a clinical trial evaluating the MitraClip Valve Repair System, a minimally invasive, non-surgical method to treat patients with mitral valve regurgitation. The catheter-based procedure inserts the device through the femoral vein in the thigh.

For more information on COAPT, visit or

OhioHealth Riverside Methodist Hospital is one of 194 centers nationwide enrolling patients for ABSORB, a clinical trial evaluating the use of a dissolvable scaffold used to open blocked heart vessels and restore blood flow. The scaffold provides support to the vessel until the artery can stay open on its own, and then dissolves naturally over time.

For more information on ABSORB, please visit

The ISCHEMIA clinical trial seeks to determine the best way to manage stable ischemic heart disease (reduced blood flow to the heart). The study will compare a conservative approach using medical therapy and lifestyle modification versus an invasive strategy, which uses cardiac catheterization and revascularization in addition to medical management.

For more information on ISCHEMIA, visit or

LEVANT is a global research project investigating the use of a drug-coated balloon to treat patients with critical limb ischemia and artery blockages below the knee. The purpose is to assess the safety and effectiveness of the Lutonix BTK Drug Coated Balloon treatment versus standard balloon angioplasty in opening arteries and preventing re-narrowing.

For more information on LEVANT, visit or

OhioHealth is recognized as a leader in revolutionary treatment of stroke, peripheral vascular disease and common cardiovascular conditions such as heart valve disease and coronary artery disease.

We actively support our clinicians as they explore innovations to improve patient care. Our goal is to engage in research that touches our patients’ lives in meaningful ways.

SAFE PCI Clinical Trial

Watch Dr. Peter Amsterdam featured in the news and see how the SAFE PCI Clinical Trial procedure works.

Dr. Peter Amsterdam, a cardiologist with HeartCare at Grant, is featured in a story about the SAFE PCI clinical trial that is evaluating getting to the heart through the wrist, transfemoral PCI versus transradial PCI, in women. Grant Medical Center and Riverside Methodist Hospital are two of only 40 sites nationally that are participating in the trial.

One of Dr. Amsterdam's patients who had a transradial procedure as part of the trial was also interviewed for the story.

Medtronic CoreValve U.S. Clinical Trial

Watch Riverside Methodist featured in the news and see how the Medtronic CoreValve U.S. Clinical Trial procedure works.

Riverside Methodist Hospital is among a select group of leading U.S. hospitals participating in a nationwide trial that gives hope to people with a life-threatening heart condition. The Medtronic CoreValve U.S. Clinical Trial is evaluating a minimally invasive alternative to open-heart surgery for patients with severe aortic stenosis, a narrowing of the aortic valve that impairs function and diminishes blood flow. Going in through the groin, the shoulder or directly between the ribs, the doctors can insert a bioprosthetic valve through a catheter without removing the native valve.

Heart and Vascular Trials and Research in the News

  • Study Uses Adult Stem Cells in Effort to Save Limbs of Patient with Peripheral Arterial Disease

    Grant Medical Center completed the nation's first published study of a new procedure that may give hope to millions of patients facing lower limb amputations from peripheral arterial disease (PAD). PAD is a painful circulatory problem in the legs that affects 10 million Americans. If left untreated, it can lead to serious complications such as amputation and death. Read more.

  • Investigational Procedure at Riverside Investigates Treatment of Aortic Aneurysms Without Major Surgery

    Riverside Methodist Hospital is part of the international trial called Ovation (Trivascular AAA), which involves a newly designed device for treatment of abdominal aortic aneurysms with no general anesthesia and is complete, start to finish, in an hour. Read more.

OhioHealth serves as a site for more than 115 heart and vascular clinical studies sponsored by industry, private non-profit organizations, and government agencies and also trials initiated by our own expert clinicians.

Over seventy of these studies are currently enrolling new patients. For more information about heart and vascular clinical trials at OhioHealth, talk to your physician. If you are seeking a physician, find a physician using our Find a Doctor feature.

Investigators and sponsors who wish to launch new clinical trials at OhioHealth are encouraged to contact the OhioHealth Research and Innovation Institute.

Clinical trials at OhioHealth involve investigational drugs, devices and other products that are currently being tested in the US. Our research activities meet the highest standards of quality and safety. For more information, please visit our Research Compliance page.