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If prednisone isn't discontinued gradually, you run the risk of developing prednisone withdrawal symptoms. So you shouldn't stop taking the drug without first consulting your doctor.

Prednisone is corticosteroid medication used to treat many conditions, including arthritis and asthma. Because long-term use of prednisone can cause serious side effects, doctors try to use the lowest dose possible for the shortest time possible. Still, there are instances when long-term prednisone therapy is needed.

Prednisone is similar to cortisol, a hormone naturally made by your adrenal glands. If you take prednisone for more than a few weeks, your adrenal glands stop making cortisol. A gradual reduction in prednisone dosages gives your adrenal glands time to resume their normal function.

If you abruptly stop taking the drug or taper off too quickly, you'll develop symptoms of prednisone withdrawal — also known as cortisol deficiency. Signs and symptoms include:

• Severe fatigue
• Weakness
• Body aches
• Nausea or vomiting
• Lightheadedness when standing (low blood pressure)

The amount of time it takes to taper off prednisone depends on the disease being treated, the dose and duration of use, and other medical considerations. A full recovery can take anywhere from a week to several months. If you experience prednisone withdrawal symptoms as you are tapering off the drug, contact your doctor.